HMM Summary Page: TIGR01191

Functionheme exporter protein CcmC
Gene SymbolccmC
Trusted Cutoff186.00
Domain Trusted Cutoff186.00
Noise Cutoff181.55
Domain Noise Cutoff181.55
Isology Typesubfamily
HMM Length184
Mainrole CategoryProtein fate
Subrole CategoryProtein and peptide secretion and trafficking
AuthorUjwal ML, Paulsen IT
Entry DateMar 4 2001 11:04PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes the cyt c biogenesis protein encoded by ccmC in bacteria. It must be noted an arabidopsis, a tritcum and a piscum plant proteins were recognizable in the clade. Quite likely they are of organellar origin. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes, ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in the heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c.
Genome PropertyGenProp0678: c-type cytochrome biogenesis, system I (HMM)