HMM Summary Page: TIGR01190

Functionheme exporter protein CcmB
Gene SymbolccmB
Trusted Cutoff156.20
Domain Trusted Cutoff156.20
Noise Cutoff29.50
Domain Noise Cutoff29.50
Isology Typeequivalog
HMM Length211
Mainrole CategoryProtein fate
Subrole CategoryProtein and peptide secretion and trafficking
Gene Ontology TermGO:0015232: heme transporter activity molecular_function
GO:0015886: heme transport biological_process
AuthorUjwal ML, Haft DH, Paulsen IT
Entry DateMar 4 2001 11:00PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes the cyt c biogenesis protein encoded by ccmB in bacteria. Bacterial c-type cytochromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes: ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome C.
Genome PropertyGenProp0678: c-type cytochrome biogenesis, system I (HMM)