HMM Summary Page: TIGR01189

Functionheme ABC exporter, ATP-binding protein CcmA
Gene SymbolccmA
Trusted Cutoff131.60
Domain Trusted Cutoff131.60
Noise Cutoff129.50
Domain Noise Cutoff129.50
Isology Typeequivalog
EC Number3.6.3.41
HMM Length198
Mainrole CategoryProtein fate
Subrole CategoryProtein and peptide secretion and trafficking
Gene Ontology TermGO:0015439: heme-transporting ATPase activity molecular_function
GO:0015886: heme transport biological_process
GO:0043190: ATP-binding cassette (ABC) transporter complex cellular_component
AuthorUjwal ML, Paulsen IT
Entry DateMar 4 2001 10:59PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes the cyt c biogenesis protein encoded by ccmA in bacteria. An exception is, an arabidopsis protein. Quite likely this is encoded by an organelle. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes: ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c.
ReferencesDR HAMAP; MF_01707; 124 of 125
Genome PropertyGenProp0678: c-type cytochrome biogenesis, system I (HMM)