| Accession | TIGR01189 |
| Name | ccmA |
| Function | heme ABC exporter, ATP-binding protein CcmA |
| Gene Symbol | ccmA |
| Trusted Cutoff | 131.60 |
| Domain Trusted Cutoff | 131.60 |
| Noise Cutoff | 129.50 |
| Domain Noise Cutoff | 129.50 |
| Isology Type | equivalog |
| EC Number | 3.6.3.41 |
| HMM Length | 198 |
| Mainrole Category | Protein fate |
| Subrole Category | Protein and peptide secretion and trafficking |
| Gene Ontology Term | GO:0015439: heme-transporting ATPase activity molecular_function |
| | GO:0015886: heme transport biological_process |
| | GO:0043190: ATP-binding cassette (ABC) transporter complex cellular_component |
| Author | Ujwal ML, Paulsen IT |
| Entry Date | Mar 4 2001 10:59PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model describes the cyt c biogenesis protein encoded by ccmA in bacteria. An exception is, an arabidopsis protein. Quite likely this is encoded by an organelle. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes: ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c. |
| References | DR HAMAP; MF_01707; 124 of 125 |
| Genome Property | GenProp0678: c-type cytochrome biogenesis, system I (HMM) |
