HMM Summary Page: TIGR01188

Functiondaunorubicin resistance ABC transporter, ATP-binding protein
Trusted Cutoff312.45
Domain Trusted Cutoff312.45
Noise Cutoff305.30
Domain Noise Cutoff305.30
Isology Typesubfamily
HMM Length302
Mainrole CategoryTransport and binding proteins
Subrole CategoryOther
Gene Ontology TermGO:0005524: ATP binding molecular_function
GO:0043190: ATP-binding cassette (ABC) transporter complex cellular_component
GO:0043215: daunorubicin transport biological_process
GO:0043216: daunorubicin-transporting ATPase activity molecular_function
AuthorUjwal ML, Paulsen IT
Entry DateMar 4 2001 10:57PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc.