HMM Summary Page: TIGR01186

Functionglycine betaine/L-proline transport ATP binding subunit
Gene SymbolproV
Trusted Cutoff326.60
Domain Trusted Cutoff326.60
Noise Cutoff315.80
Domain Noise Cutoff315.80
Isology Typesubfamily
HMM Length363
Mainrole CategoryTransport and binding proteins
Subrole CategoryAmino acids, peptides and amines
Gene Ontology TermGO:0005524: ATP binding molecular_function
GO:0009898: internal side of plasma membrane cellular_component
GO:0015837: amine transport biological_process
GO:0031263: amine-transporting ATPase activity molecular_function
GO:0043190: ATP-binding cassette (ABC) transporter complex cellular_component
AuthorUjwal ML, Paulsen IT
Entry DateMar 4 2001 10:53PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. Functionally, this transport system is involved in osmoregulation. Under conditions of stress, the organism recruits these transport system to accumulate glycine betaine and other solutes which offer osmo-protection. It has been demonstrated that glycine betaine uptake is accompanied by symport with sodium ions. The locus has been named variously as proU or opuA. A gene library from L.lactis functionally complements an E.coli proU mutant. The comlementing locus is similar to a opuA locus in B.sutlis. This clarifies the differences in nomenclature.