HMM Summary Page: TIGR01167

FunctionLPXTG cell wall anchor domain
Trusted Cutoff15.90
Domain Trusted Cutoff15.90
Noise Cutoff15.70
Domain Noise Cutoff15.70
Isology Typedomain
HMM Length34
Mainrole CategoryCell envelope
Subrole CategoryOther
Gene Ontology TermGO:0009986: cell surface cellular_component
AuthorHaft DH
Entry DateFeb 12 2001 10:54AM
Last ModifiedMar 20 2012 5:03PM
CommentThis model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region.
ReferencesRM 10754567 RT Sortase: the surface protein anchoring transpeptidase and the LPXTG motif. RA Novick RP RL Trends Microbiol 2000 Apr;8(4):148-51
Genome PropertyGenProp0626: protein sorting system, sortase type, LPXTG/SrtA class (HMM)