HMM Summary Page: TIGR01162

Functionphosphoribosylaminoimidazole carboxylase, catalytic subunit
Gene SymbolpurE
Trusted Cutoff149.60
Domain Trusted Cutoff149.60
Noise Cutoff62.25
Domain Noise Cutoff62.25
Isology Typeequivalog_domain
EC Number4.1.1.21
HMM Length156
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryPurine ribonucleotide biosynthesis
Gene Ontology TermGO:0004638: phosphoribosylaminoimidazole carboxylase activity molecular_function
GO:0009152: purine ribonucleotide biosynthetic process biological_process
GO:0009320: phosphoribosylaminoimidazole carboxylase complex cellular_component
AuthorHaft DH
Entry DateFeb 6 2001 12:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentPhosphoribosylaminoimidazole carboxylase is a fusion protein in plants and fungi, but consists of two non-interacting proteins in bacteria, PurK and PurE. This model represents PurK, an N5-CAIR mutase.
ReferencesDR SWISSPROT; P09028; PUR6_ECOLI RM 10074353 RT Evidence for the direct transfer of the carboxylate of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to generate 4-carboxy-5-aminoimidazole ribonucleotide catalyzed by Escherichia coli PurE, an N5-CAIR mutase. RA Meyer E, Kappock TJ, Osuji C, Stubbe J RL Biochemistry 1999 Mar 9;38(10):3012-8
Genome PropertyGenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM)