HMM Summary Page: TIGR01161

Functionphosphoribosylaminoimidazole carboxylase, ATPase subunit
Gene SymbolpurK
Trusted Cutoff318.40
Domain Trusted Cutoff318.40
Noise Cutoff197.10
Domain Noise Cutoff197.10
Isology Typeequivalog_domain
EC Number4.1.1.21
HMM Length362
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryPurine ribonucleotide biosynthesis
Gene Ontology TermGO:0004638: phosphoribosylaminoimidazole carboxylase activity molecular_function
GO:0009152: purine ribonucleotide biosynthetic process biological_process
GO:0009320: phosphoribosylaminoimidazole carboxylase complex cellular_component
GO:0016887: ATPase activity molecular_function
AuthorHaft DH
Entry DateFeb 6 2001 11:21AM
Last ModifiedFeb 14 2011 3:27PM
CommentPhosphoribosylaminoimidazole carboxylase is a fusion protein in plants and fungi, but consists of two non-interacting proteins in bacteria, PurK and PurE. This model represents PurK, N5-carboxyaminoimidazole ribonucleotide synthetase, which hydrolyzes ATP and converts AIR to N5-CAIR. PurE converts N5-CAIR to CAIR. In the presence of high concentrations of bicarbonate, PurE is reported able to convert AIR to CAIR directly and without ATP.
ReferencesDR SWISSPROT; P09029; PURK_ECOLI DR ECOCYC; EG10796; purK RM 10569930 RT Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily. RA Thoden JB, Kappock TJ, Stubbe J, Holden HM RL Biochemistry 1999 Nov 23;38(47):15480-92
Genome PropertyGenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM)