HMM Summary Page: TIGR01136

Functioncysteine synthase
Trusted Cutoff344.15
Domain Trusted Cutoff344.15
Noise Cutoff335.75
Domain Noise Cutoff335.75
Isology Typesubfamily
EC Number2.5.1.47
HMM Length299
Mainrole CategoryAmino acid biosynthesis
Subrole CategorySerine family
AuthorHaft DH
Entry DateJan 29 2001 2:17PM
Last ModifiedFeb 21 2012 12:26PM
CommentThis model discriminates cysteine synthases (EC (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff.
ReferencesDR COGS; COG0031