HMM Summary Page: TIGR01130

Functionprotein disulfide isomerase
Trusted Cutoff344.25
Domain Trusted Cutoff344.25
Noise Cutoff163.25
Domain Noise Cutoff163.25
Isology Typesubfamily
HMM Length476
AuthorHaft DH
Entry DateJan 22 2001 11:38AM
Last ModifiedFeb 21 2012 12:17PM
CommentThis HMM represents eukaryotic protein disulfide isomerases retained in the endoplasmic reticulum (ER) and closely related forms. Some members have been assigned alternative or additional functions such as prolyl 4-hydroxylase and dolichyl-diphosphooligosaccharide-protein glycotransferase. Members of this family have at least two protein-disulfide domains, each similar to thioredoxin but with the redox-active disulfide in the motif PWCGHCK, and an ER retention signal at the extreme C-terminus (KDEL, HDEL, and similar motifs).