HMM Summary Page: TIGR01128

FunctionDNA polymerase III, delta subunit
Gene SymbolholA
Trusted Cutoff94.95
Domain Trusted Cutoff94.95
Noise Cutoff65.15
Domain Noise Cutoff65.15
Isology Typeequivalog
EC Number2.7.7.7
HMM Length314
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0003887: DNA-directed DNA polymerase activity molecular_function
GO:0006260: DNA replication biological_process
GO:0009360: DNA polymerase III complex cellular_component
AuthorDurkin S, Haft DH
Entry DateJan 17 2001 12:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentDNA polymerase III delta (holA) and delta prime (holB) subunits are distinct proteins encoded by separate genes. The delta prime subunit (holB) exhibits sequence homology to the tau and gamma subunits (dnaX), but the delta subunit (holA) does not demonstrate this same homology with dnaX. The delta, delta prime, gamma, chi and psi subunits form the gamma complex subassembly of DNA polymerase III holoenzyme, which couples ATP to assemble the ring-shaped beta subunit around DNA forming a DNA sliding clamp.
ReferencesRN [1] RM 8505303 RT DNA polymerase III accessory proteins. I. holA and holB encoding delta and delta'. RA Dong Z, Onrust R, Skangalis M, O'Donnell M RL J Biol Chem 1993 Jun 5;268(16):11758-65 RN [2] RM 8505304 RT DNA polymerase III accessory proteins. II. Characterization of delta and delta'. RA Onrust R, O'Donnell M RL J Biol Chem 1993 Jun 5;268(16):11766-72
Genome PropertyGenProp0263: DNA polymerase III, bacterial (HMM)