HMM Summary Page: TIGR01121

FunctionD-amino-acid transaminase
Gene Symboldat
Trusted Cutoff277.45
Domain Trusted Cutoff277.45
Noise Cutoff155.80
Domain Noise Cutoff155.80
Isology Typeequivalog
EC Number2.6.1.21
HMM Length276
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0019480: L-alanine oxidation to pyruvate via D-alanine biological_process
GO:0047810: D-alanine:2-oxoglutarate aminotransferase activity molecular_function
AuthorHaft DH
Entry DateJan 12 2001 2:33PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme is a homodimer. The pyridoxal phosphate attachment site is the Lys at position 146 of the seed alignment, in the motif Cys-Asp-Ile-Lys-Ser-Leu-Asn. Specificity is broad for various D-amino acids, and differs among members of the family; the family is designated equivalog, but with this caveat attached.
ReferencesRM 89123327 RT Thermostable D-amino acid aminotransferase from a thermophilic Bacillus species. Purification, characterization, and active site sequence determination. RA Tanizawa K, Masu Y, Asano S, Tanaka H, Soda K RL J Biol Chem 1989 Feb 15;264(5):2445-9