HMM Summary Page: TIGR01114

FunctionN5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit H
Gene SymbolmtrH
Trusted Cutoff271.40
Domain Trusted Cutoff271.40
Noise Cutoff115.00
Domain Noise Cutoff115.00
Isology Typeequivalog
EC Number2.1.1.86
HMM Length314
Mainrole CategoryEnergy metabolism
Subrole CategoryMethanogenesis
Gene Ontology TermGO:0015948: methanogenesis biological_process
GO:0030269: tetrahydromethanopterin S-methyltransferase activity molecular_function
AuthorUjwal ML, Paulsen IT
Entry DateJan 9 2001 4:13PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes N5-methyltetrahydromethanopterin: coenzyme M methyltransferase subunit H in methanogenic archaea. This methyltranfersae is membrane-associated enzyme complex that uses methyl-transfer reaction to drive sodium-ion pump. Archaea have evolved energy-yielding pathways marked by one-carbon biochemistry featuring novel cofactors and enzymes. This transferase is involved in the transfer of 'methyl' group from N5-methyltetrahydromethanopterin to coenzyme M. In an accompanying reaction, methane is produced by two-electron reduction of methyl-coenzyme M by another enzyme methyl-coenzyme M reductase.
References DR HAMAP; MF_01501; 11 of 11
Genome PropertyGenProp0288: tetrahydromethanopterin S-methyltransferase complex (HMM)
GenProp0722: methanogenesis marker set (HMM)