HMM Summary Page: TIGR01113

Functiontetrahydromethanopterin S-methyltransferase, subunit E
Gene SymbolmtrE
Trusted Cutoff238.35
Domain Trusted Cutoff238.35
Noise Cutoff81.90
Domain Noise Cutoff81.90
Isology Typeequivalog
EC Number2.1.1.86
HMM Length283
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
Gene Ontology TermGO:0006810: transport biological_process
GO:0019386: methanogenesis, from carbon dioxide biological_process
GO:0030269: tetrahydromethanopterin S-methyltransferase activity molecular_function
AuthorUjwal ML, Haft DH, Paulsen IT
Entry DateJan 9 2001 4:12PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes N5-methyltetrahydromethanopterin: coenzyme M methyltransferase subunit E in methanogenic archaea. This methyltranfersae is membrane-associated enzyme complex that uses methyl-transfer reaction to drive sodium-ion pump. Archaea have evolved energy-yielding pathways marked by one-carbon biochemistry featuring novel cofactors and enzymes. This transferase is involved in the transfer of 'methyl' group from N5-methyltetrahydromethanopterin to coenzyme M. In an accompanying reaction, methane is produced by two-electron reduction of methyl-coenzyme M by another enzyme methyl-coenzyme M reductase.
ReferencesRM 9559648 RT Cloning, sequencing and expression of the genes encoding the sodium translocating N5-methyltetrahydromethanopterin: coenzyme M methyltransferase of the methylotrophic archaeon Methanosarcina mazei Go1. RA Lienard T, Gottschalk G. RL FEBS Lett 1998 Mar 27;425(2):204-8 DR HAMAP; MF_01098; 14 of 15
Genome PropertyGenProp0288: tetrahydromethanopterin S-methyltransferase complex (HMM)
GenProp0722: methanogenesis marker set (HMM)