HMM Summary Page: TIGR01112

Functiontetrahydromethanopterin S-methyltransferase, subunit D
Gene SymbolmtrD
Trusted Cutoff126.85
Domain Trusted Cutoff126.85
Noise Cutoff101.85
Domain Noise Cutoff101.85
Isology Typeequivalog
EC Number2.1.1.86
HMM Length223
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
Gene Ontology TermGO:0006810: transport biological_process
GO:0019386: methanogenesis, from carbon dioxide biological_process
GO:0030269: tetrahydromethanopterin S-methyltransferase activity molecular_function
AuthorUjwal ML, Haft DH, Paulsen IT
Entry DateJan 9 2001 4:11PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes N5-methyltetrahydromethanopterin: coenzyme M methyltransferase subunit D in methanogenic archaea. This methyltranferase is membrane-associated enzyme complex that uses methy-transfer reaction to drive sodium-ion pump. Archaea domain, have evolved energy-yielding pathways marked by one-carbon biochemistry featuring novel cofactors and enzymes. This transferase is involved in the transfer of 'methyl' group from N5-methyltetrahydromethanopterin to coenzyme M. In an accompanying reaction, methane is produced by two-electron reduction of the methyl moiety in methyl-coenzyme M by another enzyme methyl-coenzyme M reductase.
ReferencesDR EXPERIMENTAL; SP|P80653; Methanosarcina mazei RM 9559648 RT Cloning, sequencing and expression of the genes encoding the sodium translocating N5-methyltetrahydromethanopterin: coenzyme M methyltransferase of the methylotrophic archaeon Methanosarcina mazei Go1. RA Lienard T, Gottschalk G. RL FEBS Lett 1998 Mar 27;425(2):204-8 DR HAMAP; MF_01097; 8 of 8
Genome PropertyGenProp0288: tetrahydromethanopterin S-methyltransferase complex (HMM)
GenProp0722: methanogenesis marker set (HMM)