| Accession | TIGR01111 |
| Name | mtrA |
| Function | tetrahydromethanopterin S-methyltransferase, subunit A |
| Gene Symbol | mtrA |
| Trusted Cutoff | 249.15 |
| Domain Trusted Cutoff | 249.15 |
| Noise Cutoff | 173.85 |
| Domain Noise Cutoff | 173.85 |
| Isology Type | equivalog |
| EC Number | 2.1.1.86 |
| HMM Length | 238 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Cations and iron carrying compounds |
| Gene Ontology Term | GO:0006814: sodium ion transport biological_process |
| | GO:0015948: methanogenesis biological_process |
| | GO:0016020: membrane cellular_component |
| | GO:0030269: tetrahydromethanopterin S-methyltransferase activity molecular_function |
| Author | Ujwal ML, Paulsen IT |
| Entry Date | Jan 9 2001 4:10PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model describes N5-methyltetrahydromethanopterin:
coenzyme M methyltransferase subunit A in methanogenic archaea. This methyltranferase is a membrane-associated enzyme complex that uses methyl-transfer reaction to drive sodium-ion pump. Archaea have evolved energy-yielding pathways marked by one-carbon biochemistry featuring novel cofactors and enzymes. This transferase (encoded by subunit A) is involved in the transfer of 'methyl' group from N5-methyltetrahydromethanopterin to coenzyme M. In an accompanying reaction, methane is produced by two-electron reduction of methyl-coenzyme M by another enzyme, methyl-coenzyme M reductase. |
| References | RM 9559648
RT Cloning, sequencing and expression of the genes encoding the sodium translocating N5-methyltetrahydromethanopterin: coenzyme M methyltransferase of the methylotrophic archaeon Methanosarcina mazei Go1.
RA Lienard T, Gottschalk G.
RL FEBS Lett 1998 Mar 27;425(2):204-8
DR HAMAP; MF_01093; 8 of 8 |
| Genome Property | GenProp0284: cobalamin-utilizing enzymes (HMM) |
| | GenProp0288: tetrahydromethanopterin S-methyltransferase complex (HMM) |
| | GenProp0722: methanogenesis marker set (HMM) |
