HMM Summary Page: TIGR01111

Functiontetrahydromethanopterin S-methyltransferase, subunit A
Gene SymbolmtrA
Trusted Cutoff249.15
Domain Trusted Cutoff249.15
Noise Cutoff173.85
Domain Noise Cutoff173.85
Isology Typeequivalog
EC Number2.1.1.86
HMM Length238
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
Gene Ontology TermGO:0006814: sodium ion transport biological_process
GO:0015948: methanogenesis biological_process
GO:0016020: membrane cellular_component
GO:0030269: tetrahydromethanopterin S-methyltransferase activity molecular_function
AuthorUjwal ML, Paulsen IT
Entry DateJan 9 2001 4:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes N5-methyltetrahydromethanopterin: coenzyme M methyltransferase subunit A in methanogenic archaea. This methyltranferase is a membrane-associated enzyme complex that uses methyl-transfer reaction to drive sodium-ion pump. Archaea have evolved energy-yielding pathways marked by one-carbon biochemistry featuring novel cofactors and enzymes. This transferase (encoded by subunit A) is involved in the transfer of 'methyl' group from N5-methyltetrahydromethanopterin to coenzyme M. In an accompanying reaction, methane is produced by two-electron reduction of methyl-coenzyme M by another enzyme, methyl-coenzyme M reductase.
ReferencesRM 9559648 RT Cloning, sequencing and expression of the genes encoding the sodium translocating N5-methyltetrahydromethanopterin: coenzyme M methyltransferase of the methylotrophic archaeon Methanosarcina mazei Go1. RA Lienard T, Gottschalk G. RL FEBS Lett 1998 Mar 27;425(2):204-8 DR HAMAP; MF_01093; 8 of 8
Genome PropertyGenProp0284: cobalamin-utilizing enzymes (HMM)
GenProp0288: tetrahydromethanopterin S-methyltransferase complex (HMM)
GenProp0722: methanogenesis marker set (HMM)