HMM Summary Page: TIGR01110

Functionmalonate decarboxylase, alpha subunit
Gene SymbolmdcA
Trusted Cutoff789.15
Domain Trusted Cutoff789.15
Noise Cutoff313.85
Domain Noise Cutoff313.85
Isology Typeequivalog
HMM Length543
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
Gene Ontology TermGO:0006810: transport biological_process
GO:0015451: decarboxylation-driven active transmembrane transporter activity molecular_function
AuthorUjwal ML, Haft DH, Paulsen IT
Entry DateJan 9 2001 4:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes malonate decarboxylase alpha subunit, from both the water-soluble form as found in Klebsiella pneumoniae and the form couple to sodium ion pumping in Malonomonas rubra. Malonate decarboxylase Na+ pump is the paradigm of the family of Na+ transport decarboxylases. Essentially, it couples the energy derived from decarboxylation of a carboxylic acid substrate to move Na+ ion across the bilayer. Functional malonate decarboylase is a multi subunit protein. The alpha subunit enzymatically performs the transfer of malonate (substrate) to an acyl carrier protein subunit for subsequent decarboxylation, hence the name: acetyl-S-acyl carrier protein:malonate carrier protein-SH transferase.
ReferencesRN [1] RM PMID: 11902724 RT Enzymic and genetic basis for bacterial growth on malonate. RA Dimroth P, Hilbi H RL Mol Microbiol. 1997 Jul;25(1):3-10.
Genome PropertyGenProp0674: malonate decarboxylase (HMM)