HMM Summary Page: TIGR01104

FunctionV-type H(+)-translocating pyrophosphatase
Trusted Cutoff651.90
Domain Trusted Cutoff651.90
Noise Cutoff283.60
Domain Noise Cutoff283.60
Isology Typeequivalog
EC Number3.6.1.1
HMM Length697
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
Gene Ontology TermGO:0005887: integral to plasma membrane cellular_component
GO:0009678: hydrogen-translocating pyrophosphatase activity molecular_function
GO:0015992: proton transport biological_process
AuthorUjwal ML, Haft DH, Paulsen IT
Entry DateJan 9 2001 4:00PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes proton pyrophosphatases from eukaryotes (predominantly plants), archaea and bacteria. It is an integral membrane protein and is suggested to have about 15 membrane spanning domains. Proton translocating inorganic pyrophosphatase, like H(+)-ATPase, acidifies the vacuoles and is pivotal to the vacuolar secondary active transport systems in plants.
ReferencesRM 10556526 RT A thermostable vacuolar-type membrane pyrophosphatase from the archaeon Pyrobaculum aerophilum: implications for the origins of pyrophosphate-energized pumps. RA Drozdowicz YM, Lu YP, Patel V, Fitz-Gibbon S, Miller JH, Rea PA. RL FEBS Lett 1999 Nov 5;460(3):505-12 DR HAMAP; MF_01130; 22 of 31