HMM Summary Page: TIGR01098

Functionphosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein
Gene SymbolphnD
Trusted Cutoff112.05
Domain Trusted Cutoff112.05
Noise Cutoff84.30
Domain Noise Cutoff84.30
Isology Typesubfamily
HMM Length253
Mainrole CategoryTransport and binding proteins
Subrole CategoryAnions
Gene Ontology TermGO:0030288: outer membrane-bounded periplasmic space cellular_component
GO:0031362: anchored to external side of plasma membrane cellular_component
GO:0043168: anion binding molecular_function
GO:0043225: anion transmembrane-transporting ATPase activity molecular_function
GO:0055052: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing cellular_component
AuthorHaft DH, Loftus BJ
Entry DateJan 5 2001 6:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentPhosphonates are a varied class of phosphorus-containing organic compound in which a direct C-P bond is found, rather than a C-O-P linkage of the phosphorus through an oxygen atom. They may be toxic but also may be used as sources of phosphorus and energy by various bacteria. Phosphonate utilization systems typically are encoded in 14 or more genes, including a three gene ABC transporter. This family includes the periplasmic binding protein component of ABC transporters for phosphonates [1] as well as other, related binding components for closely related substances such as phosphate [2] and phosphite [3]. A number of members of this family are found in genomic contexts with components of selenium metabolic processes suggestive of a role in selenate or other selenium-compound transport. A subset of this model in which nearly all members exhibit genomic context with elements of phosphonate metabolism, particularly the C-P lyase system (GenProp0232, [4]) has been built (TIGR03431) as an equivalog. Nevertheless, there are members of this subfamily (TIGR01098) which show up sporadically on a phylogenetic tree that also show phosphonate context and are most likely competent to transport phosphonates.
ReferencesDR URL; RN [1] RM PMID:16751609 RT Identification of cognate ligands for the Escherichia coli phnD protein product and engineering of a reagentless fluorescent biosensor for phosphonates. RA Rizk SS, Cuneo MJ, Hellinga HW RL Protein Sci. 2006 Jul;15(7):1745-51. Epub 2006 Jun 2. RN [2] RM 17074913 RT The Phn system of Mycobacterium smegmatis: a second high-affinity ABC-transporter for phosphate. RA Gebhard S, Tran SL, Cook GM RL Microbiology. 2006 Nov;152(Pt 11):3453-65. RN [3] RM PMID:15317793 RT The htx and ptx operons of Pseudomonas stutzeri WM88 are new members of the pho regulon. RA White AK, Metcalf WW RL J Bacteriol. 2004 Sep;186(17):5876-82. RN [4] RM PMID:8335257 RT Evidence for a fourteen-gene, phnC to phnP locus for phosphonate metabolism in Escherichia coli. RA Metcalf WW, Wanner BL RL Gene. 1993 Jul 15;129(1):27-32.
Genome PropertyGenProp0232: phosphonates C-P lyase system (MANUAL)
GenProp0236: phosphonates ABC transport (MANUAL)