| Accession | TIGR01085 |
| Name | murE |
| Function | UDP-N-acetylmuramyl-tripeptide synthetase |
| Gene Symbol | murE |
| Trusted Cutoff | 257.30 |
| Domain Trusted Cutoff | 257.30 |
| Noise Cutoff | 204.35 |
| Domain Noise Cutoff | 204.35 |
| Isology Type | subfamily |
| HMM Length | 472 |
| Mainrole Category | Cell envelope |
| Subrole Category | Biosynthesis and degradation of murein sacculus and peptidoglycan |
| Author | Haft DH |
| Entry Date | Dec 20 2000 11:21AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate.
A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. |
| References | RM 99429836
RT Expression of the Staphylococcus aureus UDP-N-acetylmuramoyl- L-alanyl-D-glutamate:L-lysine ligase in Escherichia coli and effects on peptidoglycan biosynthesis and cell growth.
RA Mengin-Lecreulx D, Falla T, Blanot D, van Heijenoort J, Adams DJ, Chopra I
RL J Bacteriol 1999 Oct;181(19):5909-14
DR HAMAP; MF_00208; 205 of 205 |
| Genome Property | GenProp0158: peptidoglycan(murein) biosynthesis (HMM) |
