HMM Summary Page: TIGR01085

FunctionUDP-N-acetylmuramyl-tripeptide synthetase
Gene SymbolmurE
Trusted Cutoff257.30
Domain Trusted Cutoff257.30
Noise Cutoff204.35
Domain Noise Cutoff204.35
Isology Typesubfamily
HMM Length472
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of murein sacculus and peptidoglycan
AuthorHaft DH
Entry DateDec 20 2000 11:21AM
Last ModifiedFeb 14 2011 3:27PM
CommentMost members of this family are EC, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown.
ReferencesRM 99429836 RT Expression of the Staphylococcus aureus UDP-N-acetylmuramoyl- L-alanyl-D-glutamate:L-lysine ligase in Escherichia coli and effects on peptidoglycan biosynthesis and cell growth. RA Mengin-Lecreulx D, Falla T, Blanot D, van Heijenoort J, Adams DJ, Chopra I RL J Bacteriol 1999 Oct;181(19):5909-14 DR HAMAP; MF_00208; 205 of 205
Genome PropertyGenProp0158: peptidoglycan(murein) biosynthesis (HMM)