| Accession | TIGR01076 |
| Name | sortase_fam |
| Function | sortase |
| Trusted Cutoff | 39.35 |
| Domain Trusted Cutoff | 39.35 |
| Noise Cutoff | 21.95 |
| Domain Noise Cutoff | 21.95 |
| Isology Type | subfamily |
| EC Number | 3.4.22.- |
| HMM Length | 136 |
| Mainrole Category | Cell envelope |
| Subrole Category | Other |
| Gene Ontology Term | GO:0008233: peptidase activity molecular_function |
| | GO:0045184: establishment of protein localization biological_process |
| | GO:0051605: protein maturation by peptide bond cleavage biological_process |
| Author | Haft DH |
| Entry Date | Dec 15 2000 4:15PM |
| Last Modified | Sep 23 2011 9:22AM |
| Comment | This family includes Staphylococcus aureus sortase, a transpeptidase that attaches surface proteins by the Thr
of an LPXTG motif to the cell wall. It also includes a protein required for correct assembly of an LPXTG-containing fimbrial protein, a set of homologous proteins from Streptococcus pneumoniae, in which LPXTG proteins are common. However, related proteins are found in Bacillus subtilis and Methanobacterium thermoautotrophicum, in which LPXTG-mediated cell wall attachment is not known. |
| References | RN [1]
RM 99357874
RT Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall.
RA Mazmanian SK, Liu G, Ton-That H, Schneewind O.
RL Science 1999 Jul 30;285(5428):760-3 |
| Genome Property | GenProp0626: protein sorting system, sortase type, LPXTG/SrtA class (HMM) |
