HMM Summary Page: TIGR01065

Functionchannel protein, hemolysin III family
Trusted Cutoff172.20
Domain Trusted Cutoff172.20
Noise Cutoff28.05
Domain Noise Cutoff28.05
Isology Typesubfamily
HMM Length204
Gene Ontology TermGO:0015267: channel activity molecular_function
GO:0019835: cytolysis biological_process
AuthorHaft DH
Entry DateDec 6 2000 1:45PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens and Drosophila. In Bacillus cereus, a pathogen, it has been show to function as a channel-forming cytolysin. The human protein is expressed preferentially in mature macrophages, consistent with a role cytolytic role.
ReferencesRN [1] DR EXPERIMENTAL; EGAD|38000|39576; Bacillus cereus hemolysisn III RM 97071728 RT Mechanism of action of hemolysin III from Bacillus cereus. RA Baida GE, Kuzmin NP RL Biochim Biophys Acta 1996 Oct 23;1284(2):122-4 RN [2] RM 96106867 RT Molecular cloning of a novel macrophage maturation-associated transcript encoding a protein with several potential transmembrane domains. RA Rehli M, Krause SW, Schwarzfischer L, Kreutz M, Andreesen R RL Biochem. Biophys. Res. Commun. 217 (2), 661-667 (1995)