HMM Summary Page: TIGR01056

FunctionDNA topoisomerase III
Gene SymboltopB
Trusted Cutoff515.75
Domain Trusted Cutoff515.75
Noise Cutoff356.40
Domain Noise Cutoff356.40
Isology Typesubfamily
EC Number5.99.1.2
HMM Length706
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0003677: DNA binding molecular_function
GO:0003917: DNA topoisomerase type I activity molecular_function
GO:0006265: DNA topological change biological_process
AuthorUjwal ML, Haft DH
Entry DateNov 30 2000 11:09AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent.
ReferencesRM 97382294 RT The traE gene of plasmid RP4 encodes a homologue of Escherichia coli DNA topoisomerase III. RA Li Z, Hiasa H, Kumar U, DiGate RJ RL J Biol Chem 1997 Aug 1;272(31):19582-7