HMM Summary Page: TIGR01055

FunctionDNA topoisomerase IV, B subunit
Gene SymbolparE
Trusted Cutoff723.35
Domain Trusted Cutoff723.35
Noise Cutoff680.20
Domain Noise Cutoff680.20
Isology Typeequivalog
EC Number5.99.1.-
HMM Length625
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0003918: DNA topoisomerase (ATP-hydrolyzing) activity molecular_function
GO:0006265: DNA topological change biological_process
GO:0009340: DNA topoisomerase IV complex cellular_component
AuthorHaft DH
Entry DateNov 29 2000 4:43PM
Last ModifiedFeb 14 2011 3:27PM
CommentOperationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. This protein is active as an alpha(2)beta(2) heterotetramer.