HMM Summary Page: TIGR01054

Functionreverse gyrase
Gene Symbolrgy
Trusted Cutoff471.70
Domain Trusted Cutoff471.70
Noise Cutoff469.70
Domain Noise Cutoff469.70
Isology Typeequivalog
EC Number3.6.4.12
HMM Length1172
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0003678: DNA helicase activity molecular_function
GO:0003916: DNA topoisomerase activity molecular_function
GO:0003917: DNA topoisomerase type I activity molecular_function
GO:0006265: DNA topological change biological_process
AuthorUjwal ML, Haft DH
Entry DateNov 28 2000 5:52PM
Last ModifiedDec 19 2011 1:09PM
CommentThis model describes reverse gyrase, found in both archaeal and bacterial thermophiles. This enzyme, a fusion of a type I topoisomerase domain and a helicase domain, introduces positive supercoiling to increase the melting temperature of DNA double strands. Generally, these gyrases are encoded as a single polypeptide. An exception was found in Methanopyrus kandleri, where enzyme is split within the topoisomerase domain, yielding a heterodimer of gene products designated RgyB and RgyA.
ReferencesDR HAMAP; MF_01125; 19 of 19