HMM Summary Page: TIGR01033

FunctionDNA-binding regulatory protein, YebC/PmpR family
Trusted Cutoff208.75
Domain Trusted Cutoff208.75
Noise Cutoff139.65
Domain Noise Cutoff139.65
Isology Typesubfamily
HMM Length238
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0003677: DNA binding molecular_function
GO:0005737: cytoplasm cellular_component
GO:0045449: regulation of transcription biological_process
AuthorHaft DH, Ujwal ML
Entry DateNov 13 2000 4:19PM
Last ModifiedMay 27 2014 3:50PM
CommentThis model describes a minimally characterized protein family, restricted to bacteria excepting for some eukaryotic sequences that have possible transit peptides. YebC from E. coli is crystallized, and PA0964 from Pseudomonas aeruginosa has been shown to be a sequence-specific DNA-binding regulatory protein. In silico analysis suggests a role in Holliday junction resolution.
ReferencesRN [1] RM PMID:23046553 RT In silico identification of a multi-functional regulatory protein involved in Holliday junction resolution in bacteria. RA Zhang Y, Lin J, Gao Y RL BMC Syst Biol. 2012 Jul 16;6 Suppl 1:S20. doi: 10.1186/1752-0509-6-S1-S20. RN [2] RM PMID:18641136 RT The YebC family protein PA0964 negatively regulates the Pseudomonas aeruginosa quinolone signal system and pyocyanin production. RA Liang H, Li L, Dong Z, Surette MG, Duan K RL J Bacteriol. 2008 Sep;190(18):6217-27. Epub 2008 Jul 18. DR COGS; COG0217 DR HAMAP; MF_00693; 487 of 518