HMM Summary Page: TIGR01016

Functionsuccinate-CoA ligase, beta subunit
Gene SymbolsucC
Trusted Cutoff375.55
Domain Trusted Cutoff375.55
Noise Cutoff167.75
Domain Noise Cutoff167.75
Isology Typesubfamily
EC Number6.2.1.-
HMM Length386
Mainrole CategoryEnergy metabolism
Subrole CategoryTCA cycle
Gene Ontology TermGO:0004774: succinate-CoA ligase activity molecular_function
GO:0004775: succinate-CoA ligase (ADP-forming) activity molecular_function
GO:0004776: succinate-CoA ligase (GDP-forming) activity molecular_function
GO:0006099: tricarboxylic acid cycle biological_process
AuthorHaft DH
Entry DateNov 6 2000 11:33AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model is designated subfamily because it does not discriminate the ADP-forming enzyme ((EC from the GDP_forming (EC enzyme. The N-terminal half is described by the CoA-ligases HMM (PF00549). The C-terminal half is described by the ATP-grasp HMM (PF02222). This family contains a split seen both in a maximum parsimony tree (which ignores gaps) and in the gap pattern near position 85 of the seed alignment. Eukaryotic and most bacterial sequences are longer and contain a region similar to TXQTXXXG. Sequences from Deinococcus radiodurans, Mycobacterium tuberculosis, Streptomyces coelicolor, and the Archaea are 6 amino acids shorter in that region and contain a motif resembling [KR]G
ReferencesDR COGS; COG0045 DR HAMAP; MF_00558; 358 of 363
Genome PropertyGenProp0033: TCA cycle (HMM)