HMM Summary Page: TIGR00979

Functionfumarate hydratase, class II
Gene SymbolfumC
Trusted Cutoff664.75
Domain Trusted Cutoff664.75
Noise Cutoff524.85
Domain Noise Cutoff524.85
Isology Typeequivalog
EC Number4.2.1.2
HMM Length458
Mainrole CategoryEnergy metabolism
Subrole CategoryTCA cycle
Gene Ontology TermGO:0004333: fumarate hydratase activity molecular_function
GO:0006099: tricarboxylic acid cycle biological_process
AuthorHaft DH
Entry DateOct 2 2000 1:49PM
Last ModifiedFeb 14 2011 3:27PM
CommentPutative fumarases from several species (Mycobacterium tuberculosis, Streptomyces coelicolor, Pseudomonas aeruginosa) branch deeply, although within the same branch of a phylogenetic tree rooted by aspartate ammonia-lyase sequences, and score between the trusted and noise cutoffs.
ReferencesDR OUTGROUP; EGAD|17758|BS2353; aspartate ammonia-lyase; Bacillus subtilis DR OUTGROUP; EGAD|23805|EC4139; aspartate ammonia-lyase; Escherichia coli DR HAMAP; MF_00743; 72 of 87
Genome PropertyGenProp0033: TCA cycle (HMM)
GenProp0033: TCA cycle (HMM)
GenProp0755: pyruvate conversion to propionate, anaerobic, FAD/NAD-regenerating (HMM)