HMM Summary Page: TIGR00973

Function2-isopropylmalate synthase
Gene SymbolleuA
Trusted Cutoff598.70
Domain Trusted Cutoff598.70
Noise Cutoff597.20
Domain Noise Cutoff597.20
Isology Typeequivalog
EC Number2.3.3.13
HMM Length494
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryPyruvate family
Gene Ontology TermGO:0003852: 2-isopropylmalate synthase activity molecular_function
GO:0009098: leucine biosynthetic process biological_process
AuthorHaft DH
Entry DateSep 29 2000 11:32AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis is the first enzyme of leucine biosynthesis. A larger family of homologous proteins includes homocitrate synthase, distinct lineages of 2-isopropylmalate synthase, several distinct, uncharacterized, orthologous sets in the Archaea, and other related enzymes. This model describes a family of 2-isopropylmalate synthases found primarily in Bacteria. The homologous families in the Archaea may represent isozymes and/or related enzymes.
References DR HAMAP; MF_01025; 77 of 96
Genome PropertyGenProp0164: leucine biosynthesis from pyruvate and acetyl-CoA (HMM)