Accession | TIGR00973 |
Name | leuA_bact |
Function | 2-isopropylmalate synthase |
Gene Symbol | leuA |
Trusted Cutoff | 598.70 |
Domain Trusted Cutoff | 598.70 |
Noise Cutoff | 597.20 |
Domain Noise Cutoff | 597.20 |
Isology Type | equivalog |
EC Number | 2.3.3.13 |
HMM Length | 494 |
Mainrole Category | Amino acid biosynthesis |
Subrole Category | Pyruvate family |
Gene Ontology Term | GO:0003852: 2-isopropylmalate synthase activity molecular_function |
| GO:0009098: leucine biosynthetic process biological_process |
Author | Haft DH |
Entry Date | Sep 29 2000 11:32AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This is the first enzyme of leucine biosynthesis.
A larger family of homologous proteins includes homocitrate synthase, distinct lineages of 2-isopropylmalate synthase, several distinct, uncharacterized, orthologous sets in the Archaea, and other related enzymes. This model describes a family of 2-isopropylmalate synthases found primarily in Bacteria. The homologous families in the Archaea may represent isozymes and/or related enzymes. |
References |
DR HAMAP; MF_01025; 77 of 96 |
Genome Property | GenProp0164: leucine biosynthesis from pyruvate and acetyl-CoA (HMM) |