HMM Summary Page: TIGR00970

Function2-isopropylmalate synthase
Gene SymbolleuA
Trusted Cutoff697.40
Domain Trusted Cutoff697.40
Noise Cutoff244.35
Domain Noise Cutoff244.35
Isology Typeequivalog
EC Number2.3.3.13
HMM Length564
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryPyruvate family
Gene Ontology TermGO:0003852: 2-isopropylmalate synthase activity molecular_function
GO:0009098: leucine biosynthetic process biological_process
AuthorHaft DH
Entry DateSep 29 2000 10:59AM
Last ModifiedFeb 14 2011 3:27PM
CommentA larger family of homologous proteins includes homocitrate synthase, distinct lineages of 2-isopropylmalate synthase, several distinct, uncharacterized, orthologous sets in the Archaea, and other related enzymes. This model describes a family of 2-isopropylmalate synthases as found in yeasts and in a minority of studied bacteria.
References DR HAMAP; MF_00572; 30 of 31
Genome PropertyGenProp0164: leucine biosynthesis from pyruvate and acetyl-CoA (HMM)