HMM Summary Page: TIGR00965

Function2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
Gene SymboldapD
Trusted Cutoff375.40
Domain Trusted Cutoff375.40
Noise Cutoff53.60
Domain Noise Cutoff53.60
Isology Typeequivalog
EC Number2.3.1.117
HMM Length271
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAspartate family
Gene Ontology TermGO:0008666: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity molecular_function
GO:0009089: lysine biosynthetic process via diaminopimelate biological_process
AuthorHaft DH
Entry DateSep 28 2000 2:53PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme is part of the diaminopimelate pathway of lysine biosynthesis. Alternate name: tetrahydrodipicolinate N-succinyltransferase. The closely related TabB protein of Pseudomonas syringae (pv. tabaci), SP|P31852|TABB_PSESZ, appears to act in the biosynthesis of tabtoxin rather than lysine. The trusted cutoff is set high enough to exclude this gene. Sequences below trusted also include a version of this enzyme which apparently utilize acetate rather than succinate (EC:
ReferencesRN [1] RM PMID:9294453 RT A possible role for acetylated intermediates in diaminopimelate and tabtoxinine-beta-lactam biosynthesis in Pseudomonas syringae pv. tabaci BR2.024. RA Liu L, Shaw PD RL J Bacteriol. 1997 Sep;179(18):5922-7. DR HAMAP; MF_00811; 185 of 190
Genome PropertyGenProp0786: lysine biosynthesis via diaminopimelate (DAP), succinylated branch (HMM)