HMM Summary Page: TIGR00957

Functionmulti drug resistance-associated protein (MRP)
Trusted Cutoff1470.00
Domain Trusted Cutoff1470.00
Noise Cutoff1470.00
Domain Noise Cutoff1470.00
Isology Typeequivalog
HMM Length1522
Mainrole CategoryTransport and binding proteins
Subrole CategoryOther
Gene Ontology TermGO:0006855: drug transmembrane transport biological_process
GO:0015559: multidrug efflux pump activity molecular_function
GO:0042493: response to drug biological_process
AuthorUjwal ML, Loftus BJ, Paulsen IT
Entry DateSep 26 2000 4:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux, abrogated its function. The C-terminal domain seem to highly conserved.
ReferencesRM 93088080 RT Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line RA Cole S.P.C., Bhardwaj G., Gerlach J.H., Mackie J.E., Grant C.E., Almquist K.C., Stewart A.J., Kurz E.U., Duncan A.M.V., Deeley R.G. RL Science 258:1650-1654(1992).