HMM Summary Page: TIGR00947

Functionputative bicarbonate transporter, IctB family
Gene SymbolictB
Trusted Cutoff366.40
Domain Trusted Cutoff366.40
Noise Cutoff209.65
Domain Noise Cutoff209.65
Isology Typeequivalog
HMM Length425
Mainrole CategoryTransport and binding proteins
Subrole CategoryCarbohydrates, organic alcohols, and acids
AuthorLoftus BJ, Haft DH
Entry DateSep 21 2000 11:24AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family of proteins is suggested to transport inorganic carbon (HCO3-), based on the phenotype of a mutant of IctB in Synechococcus sp. strain PCC 7942. Bicarbonate uptake is used by many photosynthetic organisms including cyanobacteria. These organisms are able to concentrate CO2/HCO3- against a greater than ten-fold concentration gradient. Cyanobacteria may have several such carriers operating with different efficiencies. Note that homology to various O-antigen ligases, with possible implications for mutant cell envelope structure, might allow alternatives to the interpretation of IctB as a bicarbonate transport protein.
ReferencesDR URL; DR Interpro; IPR006007 DR PFAM; PF04932 RN [1] RM PMID:9688546 RT A putative HCO3- transporter in the cyanobacterium Synechococcus sp. strain PCC 7942. RA Bonfil DJ, Ronen-Tarazi M, Sultemeyer D, Lieman-Hurwitz J, Schatz D, Kaplan A RL FEBS Lett. 1998 Jul 3;430(3):236-40.