HMM Summary Page: TIGR00943

Functionmonovalent cation:proton antiporter
Gene Symbolnha
Trusted Cutoff139.75
Domain Trusted Cutoff139.75
Noise Cutoff113.10
Domain Noise Cutoff113.10
Isology Typesubfamily
HMM Length107
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
Gene Ontology TermGO:0005451: monovalent cation:hydrogen antiporter activity molecular_function
GO:0015672: monovalent inorganic cation transport biological_process
GO:0015992: proton transport biological_process
AuthorLoftus BJ
Entry DateSep 20 2000 10:26AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family of proteins constists of bacterial multicomponent K+:H+ and Na+:H+ antiporters. The best characterized systems are the PhaABCDEFG system of Rhizobium meliloti which functions in pH adaptation and as a K+ efflux system and the MnhABCDEFG system of Staphylococcus aureus which functions as a Na+:H+ antiporter.This family is specific for the phaB and mnhB proteins.
ReferencesDR URL; RM PMID: 9852009 RT A putative multisubunit Na+/H+ antiporter from Staphylococcus aureus RA Hiramatsu T, Kodama K, Kuroda T, Mizushima T, Tsuchiya T. RL J Bacteriol 1998 Dec;180(24):6642-8