| Accession | TIGR00928 |
| Name | purB |
| Function | adenylosuccinate lyase |
| Gene Symbol | purB |
| Trusted Cutoff | 326.20 |
| Domain Trusted Cutoff | 326.20 |
| Noise Cutoff | 307.75 |
| Domain Noise Cutoff | 307.75 |
| Isology Type | equivalog |
| EC Number | 4.3.2.2 |
| HMM Length | 436 |
| Mainrole Category | Purines, pyrimidines, nucleosides, and nucleotides |
| Subrole Category | Purine ribonucleotide biosynthesis |
| Gene Ontology Term | GO:0004018: N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity molecular_function |
| | GO:0009152: purine ribonucleotide biosynthetic process biological_process |
| Author | Haft DH, Durkin S |
| Entry Date | Sep 13 2000 5:59PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This family consists of adenylosuccinate lyase, the enzyme that catalyzes step 8 in the purine biosynthesis pathway for de novo synthesis of IMP and also the final reaction in the two-step sequence from IMP to AMP. |
| References | DR EXPERIMENTAL; EGAD|164678|TM1095; Thermotoga maritima
DR EXPERIMENTAL; EGAD|14517|EC1131; Escherichia coli
DR EXPERIMENTAL; EGAD|2198|2146; Homo sapiens
DR OUTGROUP; EGAD|49512|slr1133; argininosuccinate lyase
DR OUTGROUP; EGAD|64123|67018; argininosuccinate lyase
RM Medline: 92104952
RT Escherichia coli purB gene: cloning, nucleotide sequence, and regulation by purR.
RA He B, Smith JM, Zalkin H.
RL J Bacteriol. 1992 Jan;174(1):130-6. |
| Genome Property | GenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM) |
| | GenProp0747: adenosine monophosphate (AMP) biosynthesis from inosine monophosphate (IMP) (HMM) |
