| Accession | TIGR00904 |
| Name | mreB |
| Function | cell shape determining protein, MreB/Mrl family |
| Trusted Cutoff | 365.75 |
| Domain Trusted Cutoff | 365.75 |
| Noise Cutoff | 146.25 |
| Domain Noise Cutoff | 146.25 |
| Isology Type | subfamily |
| HMM Length | 334 |
| Mainrole Category | Cell envelope |
| Subrole Category | Biosynthesis and degradation of murein sacculus and peptidoglycan |
| Gene Ontology Term | GO:0008360: regulation of cell shape biological_process |
| Author | Haft DH |
| Entry Date | Sep 12 2000 11:47AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | MreB (mecillinam resistance) in E. coli (also called envB) and the paralogous pair MreB and Mrl of Bacillus subtilis have all been shown to help determine cell shape. This protein is present in a wide variety of bacteria, including spirochetes, but is missing from the Mycoplasmas and from Gram-positive cocci. Most completed bacterial genomes have a single member of this family. In some species it is an essential gene.
A close homolog is found in the Archaeon Methanobacterium thermoautotrophicum, and a more distant homolog in Archaeoglobus fulgidus. The family is related to cell division protein FtsA and heat shock protein DnaK. |
| References | DR ECOCYC; EG10608; mreB |
| Genome Property | GenProp0166: mreBCD system (HMM) |
