HMM Summary Page: TIGR00904

Functioncell shape determining protein, MreB/Mrl family
Trusted Cutoff365.75
Domain Trusted Cutoff365.75
Noise Cutoff146.25
Domain Noise Cutoff146.25
Isology Typesubfamily
HMM Length334
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of murein sacculus and peptidoglycan
Gene Ontology TermGO:0008360: regulation of cell shape biological_process
AuthorHaft DH
Entry DateSep 12 2000 11:47AM
Last ModifiedFeb 14 2011 3:27PM
CommentMreB (mecillinam resistance) in E. coli (also called envB) and the paralogous pair MreB and Mrl of Bacillus subtilis have all been shown to help determine cell shape. This protein is present in a wide variety of bacteria, including spirochetes, but is missing from the Mycoplasmas and from Gram-positive cocci. Most completed bacterial genomes have a single member of this family. In some species it is an essential gene. A close homolog is found in the Archaeon Methanobacterium thermoautotrophicum, and a more distant homolog in Archaeoglobus fulgidus. The family is related to cell division protein FtsA and heat shock protein DnaK.
ReferencesDR ECOCYC; EG10608; mreB
Genome PropertyGenProp0166: mreBCD system (HMM)