HMM Summary Page: TIGR00885

FunctionL-fucose:H+ symporter permease
Gene SymbolfucP
Trusted Cutoff280.40
Domain Trusted Cutoff280.40
Noise Cutoff264.85
Domain Noise Cutoff264.85
Isology Typeequivalog
HMM Length410
Mainrole CategoryTransport and binding proteins
Subrole CategoryCarbohydrates, organic alcohols, and acids
Gene Ontology TermGO:0005887: integral to plasma membrane cellular_component
GO:0015535: fucose:hydrogen symporter activity molecular_function
GO:0015756: fucose transport biological_process
AuthorUjwal ML, Loftus BJ, Paulsen IT
Entry DateSep 11 2000 2:59PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family describes the L-fucose permease in bacteria. L-fucose(6-deoxy-L-galactose) is a monosaccharide found in glycoproteins and cell wall polysaccharides. L-fucose is used in bacteria through an inducible pathway mediated by atleast four enzymes: a permease, isomerase, kinase and an aldolase which are encoded by fucP, fucI, fucK, fucA respectively. The fuc genes belong to a regulon comprising of four linked operons: fucO, fucA, fucPIK and fucR. The positive regulator is encoded by fucR, whose protein responds to fuculose-1-phosphate, which acts as an effector.
ReferencesRM 7783647 RT Topological analyses of the L-fucose-H+ symport protein, FucP, from Escherichia coli. RA Gunn FJ, Tate CG, Sansom CE, Henderson PJ RL Mol Microbiol 1995 Feb;15(4):771-83
Genome PropertyGenProp0458: fucose catabolism (HMM)