HMM Summary Page: TIGR00878

Functionphosphoribosylformylglycinamidine cyclo-ligase
Gene SymbolpurM
Trusted Cutoff236.35
Domain Trusted Cutoff236.35
Noise Cutoff139.05
Domain Noise Cutoff139.05
Isology Typeequivalog_domain
EC Number6.3.3.1
HMM Length332
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryPurine ribonucleotide biosynthesis
Gene Ontology TermGO:0004641: phosphoribosylformylglycinamidine cyclo-ligase activity molecular_function
GO:0006189: 'de novo' IMP biosynthetic process biological_process
GO:0009152: purine ribonucleotide biosynthetic process biological_process
AuthorHaft DH
Entry DateSep 11 2000 10:26AM
Last ModifiedFeb 14 2011 3:27PM
CommentAlternate name: phosphoribosylformylglycinamidine cyclo-ligase; AIRS; AIR synthase This enzyme is found as a homodimeric monofunctional protein in prokaryotes and as part of a larger, multifunctional protein, sometimes with two copies of this enzyme in tandem, in eukaryotes.
ReferencesDR; EXPERIMENTAL; EGAD|24860|EC2499; Escherichia coli DR HAMAP; MF_00741; 323 of 326
Genome PropertyGenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM)