HMM Summary Page: TIGR00872

Function6-phosphogluconate dehydrogenase (decarboxylating)
Gene Symbolgnd
Trusted Cutoff297.20
Domain Trusted Cutoff297.20
Noise Cutoff267.50
Domain Noise Cutoff267.50
Isology Typeequivalog
EC Number1.1.1.44
HMM Length299
Mainrole CategoryEnergy metabolism
Subrole CategoryPentose phosphate pathway
Gene Ontology TermGO:0004616: phosphogluconate dehydrogenase (decarboxylating) activity molecular_function
GO:0006098: pentose-phosphate shunt biological_process
AuthorHaft DH
Entry DateSep 7 2000 4:18PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family resembles a larger family (gnd) of bacterial and eukaryotic 6-phosphogluconate dehydrogenases but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle[1]. In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle.
ReferencesRN [1] RM PMID: 10658669 RT Analysis of two formaldehyde oxidation pathways in Methylobacillus flagellatus KT, a ribulose monophosphate cycle methylotroph RA Chistoserdova L, Gomelsky L, Vorholt JA, Gomelsky M, Tsygankov YD, Lidstrom ME RL Microbiology. 2000 Jan;146 ( Pt 1):233-8
Genome PropertyGenProp0120: pentose phosphate cycle (HMM)