HMM Summary Page: TIGR00871

Functionglucose-6-phosphate dehydrogenase
Gene Symbolzwf
Trusted Cutoff400.60
Domain Trusted Cutoff400.60
Noise Cutoff195.70
Domain Noise Cutoff195.70
Isology Typeequivalog
EC Number1.1.1.49
HMM Length486
Mainrole CategoryEnergy metabolism
Subrole CategoryPentose phosphate pathway
Gene Ontology TermGO:0004345: glucose-6-phosphate dehydrogenase activity molecular_function
GO:0006098: pentose-phosphate shunt biological_process
AuthorHaft DH
Entry DateSep 5 2000 3:14PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme (EC acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC, but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff.
ReferencesDR EXPERIMENTAL; EGAD|23035|23799; Leuconostoc mesenteroides
Genome PropertyGenProp0120: pentose phosphate cycle (HMM)