HMM Summary Page: TIGR00870

Functiontransient-receptor-potential calcium channel protein
Gene Symboltrp
Trusted Cutoff498.75
Domain Trusted Cutoff498.75
Noise Cutoff352.75
Domain Noise Cutoff352.75
Isology Typesubfamily
HMM Length747
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateAug 11 2000 1:27PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4) The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteins TRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in response to depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CC family, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 to stimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and serves as a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel (SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SIC transport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell death after chronic exposure to capsaicin. (McCleskey and Gold, 1999).
ReferencesA2 hmmalign SE Iapulsen AL clustalw_manual