HMM Summary Page: TIGR00864

Functionpolycystin cation channel protein
Gene SymbolPCC
Trusted Cutoff1861.40
Domain Trusted Cutoff1861.40
Noise Cutoff1077.10
Domain Noise Cutoff1077.10
Isology Typesubfamily_domain
HMM Length2700
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateAug 11 2000 1:26PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half because a full-length model is incompatible with the HMM software package.
ReferencesSE Ipaulsen