HMM Summary Page: TIGR00863

Functioncation transporter protein
Gene SymbolP2X
Trusted Cutoff288.00
Domain Trusted Cutoff288.00
Noise Cutoff260.40
Domain Noise Cutoff260.40
Isology Typesubfamily
HMM Length372
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateAug 11 2000 1:26PM
Last ModifiedFeb 14 2011 3:27PM
CommentATP-gated Cation Channel (ACC) Family (TC 1.A.7) Members of the ACC family (also called P2X receptors) respond to ATP, a functional neurotransmitter released by exocytosis from many types of neurons. These channels, which function at neuron-neuron and neuron-smooth muscle junctions, may play roles in the control of blood pressure and pain sensation. They may also function in lymphocyte and platelet physiology. They are found only in animals. ACC channels are probably hetero- or homomultimers and transport small monovalent cations (Me+). Some also transport Ca2+; a few also transport small metabolites.
ReferencesA2 hmmalign SE Ipaulsen AL clustalw_manual