HMM Summary Page: TIGR00862

Functionintracellular chloride channel protein
Trusted Cutoff358.95
Domain Trusted Cutoff358.95
Noise Cutoff237.80
Domain Noise Cutoff237.80
Isology Typesubfamily
HMM Length236
Mainrole CategoryTransport and binding proteins
Subrole CategoryAnions
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateAug 11 2000 1:26PM
Last ModifiedJul 18 2011 3:02PM
CommentThe Organellar Chloride Channel (O-ClC) Family (TC 1.A.12) Proteins of the O-ClC family are voltage-sensitive chloride channels found in intracellular membranes but not the plasma membranes of animal cells. They are found in human nuclear membranes, and the bovine protein targets to the microsomes, but not the plasma membrane, when expressed in Xenopus laevis oocytes. These proteins are thought to function in the regulation of the membrane potential and in transepithelial ion absorption and secretion in the kidney.
ReferencesA2 hmmalign SE Ipaulsen AL clustalw_manual