HMM Summary Page: TIGR00860

Functioncation transporter family protein
Gene SymbolLIC
Trusted Cutoff280.20
Domain Trusted Cutoff280.20
Noise Cutoff233.65
Domain Noise Cutoff233.65
Isology Typesubfamily
HMM Length462
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateAug 11 2000 1:26PM
Last ModifiedMar 1 2011 11:50AM
CommentThe Ligand-gated Ion Channel (LIC) Family of Neurotransmitter Receptors TC 1.A.9) Members of the LIC family of ionotropic neurotransmitter receptors are found only in vertebrate and invertebrate animals. They exhibit receptor specificity for (1) acetylcholine, (2) serotonin, (3) glycine, (4) glutamate and (5) g-aminobutyric acid (GABA). All of these receptor channels are probably hetero- or homopentameric. The best characterized are the nicotinic acetyl-choline receptors which are pentameric channels of a2bgd subunit composition. All subunits are homologous. The three dimensional structures of the protein complex in both the open and closed configurations have been solved at 0.9 nm resolution. The channel protein complexes of the LIC family preferentially transport cations or anions depending on the channel (e.g., the acetylcholine receptors are cation selective while glycine receptors are anion selective).
ReferencesA2 hmmalign SE Ipaulsen AL clustalw_manual