HMM Summary Page: TIGR00858

Function8-amino-7-oxononanoate synthase
Gene SymbolbioF
Trusted Cutoff426.45
Domain Trusted Cutoff426.45
Noise Cutoff324.95
Domain Noise Cutoff324.95
Isology Typeequivalog
EC Number2.3.1.47
HMM Length365
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryBiotin
Gene Ontology TermGO:0008710: 8-amino-7-oxononanoate synthase activity molecular_function
GO:0009102: biotin biosynthetic process biological_process
AuthorHaft DH
Entry DateAug 10 2000 10:59AM
Last ModifiedFeb 14 2011 3:27PM
Comment7-keto-8-aminopelargonic acid synthetase is an alternate name. This model represents 8-amino-7-oxononanoate synthase, the BioF protein of biotin biosynthesis. This model is based on a careful phylogenetic analysis to separate members of this family from 2-amino-3-ketobutyrate and other related pyridoxal phosphate-dependent enzymes. In several species, including Staphylococcus and Coxiella, a candidate 8-amino-7-oxononanoate synthase is confirmed by location in the midst of a biotin biosynthesis operon but scores below the trusted cutoff of this model.
Genome PropertyGenProp0036: biotin biosynthesis (HMM)