HMM Summary Page: TIGR00857

Functiondihydroorotase, multifunctional complex type
Gene SymbolpyrC
Trusted Cutoff279.05
Domain Trusted Cutoff279.05
Noise Cutoff197.80
Domain Noise Cutoff197.80
Isology Typesubfamily_domain
EC Number3.5.2.3
HMM Length412
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryPyrimidine ribonucleotide biosynthesis
Gene Ontology TermGO:0004151: dihydroorotase activity molecular_function
GO:0009220: pyrimidine ribonucleotide biosynthetic process biological_process
AuthorHaft DH, Durkin S
Entry DateAug 3 2000 3:23PM
Last ModifiedFeb 14 2011 3:27PM
CommentIn contrast to the homodimeric type of dihydroorotase found in E. coli, this class tends to appear in a large, multifunctional complex with aspartate transcarbamoylase. Homologous domains appear in multifunctional proteins of higher eukaryotes. In some species, including Pseudomonas putida and P. aeruginosa, this protein is inactive but is required as a non-catalytic subunit of aspartate transcarbamoylase (ATCase). In these species, a second, active dihydroorotase is also present. The seed for this model does not include any example of the dihydroorotase domain of eukaryotic multidomain pyrimidine synthesis proteins. All proteins described by this HMM should represent active and inactive dihydroorotase per se and functionally equivalent domains of multifunctional proteins from higher eukaryotes, but exclude related proteins such as allantoinase.
ReferencesDR PROSITE; PDOC00401; Dihydroorotase signatures DR HAMAP; MF_01645; 2 of 26
Genome PropertyGenProp0187: pyrimidine (uridine-5'-phosphate) de novo biosynthesis (HMM)