HMM Summary Page: TIGR00854

FunctionPTS system, mannose/fructose/sorbose family, IIB component
Trusted Cutoff163.60
Domain Trusted Cutoff163.60
Noise Cutoff140.25
Domain Noise Cutoff140.25
Isology Typesubfamily
EC Number2.7.1.69
HMM Length150
Mainrole CategoryTransport and binding proteins
Subrole CategoryCarbohydrates, organic alcohols, and acids
Gene Ontology TermGO:0008982: protein-N(PI)-phosphohistidine-sugar phosphotransferase activity molecular_function
GO:0009401: phosphoenolpyruvate-dependent sugar phosphotransferase system biological_process
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 25 2000 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentBacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families.It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the IIB components of this family of PTS transporters.
ReferencesSE ipaulsen DR URL;
Genome PropertyGenProp0119: PTS transport system (HMM)