HMM Summary Page: TIGR00852

FunctionPTS system, maltose and glucose-specific subfamily, IIC component
Trusted Cutoff291.10
Domain Trusted Cutoff291.10
Noise Cutoff276.00
Domain Noise Cutoff276.00
Isology Typesubfamily_domain
HMM Length290
Mainrole CategoryTransport and binding proteins
Subrole CategoryCarbohydrates, organic alcohols, and acids
AuthorPaulsen IT, Saier MH, Loftus BJ
Entry DateJul 25 2000 6:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe PTS Glucose-Glucoside (Glc) Family (TC 4.A.1) Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the E. coli PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. This Hmm is specific for the IIC domain of the Glc family PTS transporters.
ReferencesA2 hmmalign SE ipaulsen AL clustalw_manual
Genome PropertyGenProp0119: PTS transport system (HMM)