| Accession | TIGR00848 |
| Name | fruA |
| Function | PTS system, fructose subfamily, IIA component |
| Gene Symbol | fruA |
| Trusted Cutoff | 103.50 |
| Domain Trusted Cutoff | 103.50 |
| Noise Cutoff | 95.80 |
| Domain Noise Cutoff | 95.80 |
| Isology Type | subfamily_domain |
| EC Number | 2.7.1.69 |
| HMM Length | 129 |
| Mainrole Category | Transport and binding proteins |
| Subrole Category | Carbohydrates, organic alcohols, and acids |
| Author | Haft DH, Paulsen IT, Saier MH, Loftus BJ |
| Entry Date | Jul 25 2000 6:19PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | 4.A.2 The PTS Fructose-Mannitol (Fru) Family
Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Fru family is a large and complex family which includes several sequenced fructose and mannitol-specific permeases as well as several putative PTS
permeases of unknown specificities. The fructose permeases of this family phosphorylate fructose on the 1-position. Those of family 4.6 phosphorylate fructose on the 6-position. The Fru family PTS systems typically have 3 domains, IIA, IIB and IIC, which may be found as 1 or more proteins. The fructose and mannitol transporters form separate phylogenetic clusters in this family. This Hmm is specific for the IIA domain of the fructose PTS transporters. Also similar to the Enzyme IIA Fru subunits of the PTS, but included in TIGR01419 rather than this model, is enzyme IIA Ntr (nitrogen), also called PtsN, found in E. coli and other organisms, which may play a solely regulatory role. |
| References | A2 hmmalign
SE ipaulsen
AL clustalw_manual
DR URL; http://www-biology.ucsd.edu/~msaier/transport/4_A_2.html |
| Genome Property | GenProp0119: PTS transport system (HMM) |
| | GenProp0693: fructose utilization as fructose-1,6-bisphosphate (HMM) |
