HMM Summary Page: TIGR00848

FunctionPTS system, fructose subfamily, IIA component
Gene SymbolfruA
Trusted Cutoff103.50
Domain Trusted Cutoff103.50
Noise Cutoff95.80
Domain Noise Cutoff95.80
Isology Typesubfamily_domain
EC Number2.7.1.69
HMM Length129
Mainrole CategoryTransport and binding proteins
Subrole CategoryCarbohydrates, organic alcohols, and acids
AuthorHaft DH, Paulsen IT, Saier MH, Loftus BJ
Entry DateJul 25 2000 6:19PM
Last ModifiedFeb 14 2011 3:27PM
Comment4.A.2 The PTS Fructose-Mannitol (Fru) Family Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Fru family is a large and complex family which includes several sequenced fructose and mannitol-specific permeases as well as several putative PTS permeases of unknown specificities. The fructose permeases of this family phosphorylate fructose on the 1-position. Those of family 4.6 phosphorylate fructose on the 6-position. The Fru family PTS systems typically have 3 domains, IIA, IIB and IIC, which may be found as 1 or more proteins. The fructose and mannitol transporters form separate phylogenetic clusters in this family. This Hmm is specific for the IIA domain of the fructose PTS transporters. Also similar to the Enzyme IIA Fru subunits of the PTS, but included in TIGR01419 rather than this model, is enzyme IIA Ntr (nitrogen), also called PtsN, found in E. coli and other organisms, which may play a solely regulatory role.
ReferencesA2 hmmalign SE ipaulsen AL clustalw_manual DR URL;
Genome PropertyGenProp0119: PTS transport system (HMM)
GenProp0693: fructose utilization as fructose-1,6-bisphosphate (HMM)